It's unclear if licorice is beneficial when used alone. Martin, M. D., Sherman, J., van der Ven, V., and Burgess, J. Clin Ther 1999;21(12):2080-2090. Stormer FC, Reistad R, Alexander J. Glycyrrhizic acid in liquorice - evaluation of health hazard. View abstract. Effect of glycyrrhizin on the activity of CYP3A enzyme in humans. A long-term disorder of the large intestines that causes stomach pain (irritable bowel syndrome or IBS). I. Elucidation of five new flavonoid constituents from the roots of Glycyrrhiza glabra L. collected in Xinjiang. Blumenthal, M and et al. Taking a specific licorice product containing certain antacids for 4-16 weeks might speed up ulcer healing. Purnak, T., Ozaslan, E., Beyazit, Y., and Haznedaroglu, I. C. Upper gastrointestinal bleeding in a patient with defective hemostasis successfully treated with ankaferd blood stopper. Hypertension and the cortisol-cortisone shuttle. View abstract. He, Y., Guo, Y. J., and Gao, Y. Y. View abstract. Am J Chin Med 2003;31:445-53. . J Clin Hypertens (Greenwich) 2008;10:153-7. Licorice, or licorice root, is the under-rated skincare ingredient that can help you achieve smooth and glowy complexion. Madisch A, Melderis H, Mayr G, et al. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers. View abstract. View abstract. J Hepatol 1994;21:601-9. Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis Bail. Luper, S. A review of plants used in the treatment of liver disease: part two. Panduranga P, Al-Rawahi N. Licorice-induced severe hypokalemia with recurrent torsade de pointes. View abstract. Fatal hypokalaemic alkalosis with tetany during liquorice and P.A.S. J Am Soc Nephrol 2002;13(1):191-196. View abstract. View abstract. APPLIED TO THE SKIN: Did you or will you purchase this product in-store or online? Br J Nutr. A., van Dokkum, W., and Savelkoul, T. J. Glycyrrhizic acid: the assessment of a no effect level. Gallacher SD, Tsokolas G, Dimitropoulos I. Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department. J Assoc Physicians India 1989;37(10):647. Medicine (Baltimore) 2018;97(11):e0073. A. and Cunliffe, W. J. Self-medication with liquorice in a patient with Addison's disease. Deglycyrrhizinated liquorice in aphthous ulcers. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. Uncontrolled Blood Sugar: How Dangerous Is It? View abstract. Early research shows that taking licorice doesn't reduce body weight in people who are overweight or obese. Morris DJ, Davis E, Latif SA. Yoshida S, Takayama Y. Licorice-induced hypokalemia as a treatable cause of dropped head syndrome. Menopause 2002;9:145-50. Severe hypokalemic paralysis and rhabdomyolysis due to ingestion of liquorice. Schleimer, R. P. Potential regulation of inflammation in the lung by local metabolism of hydrocortisone. Some medications for inflammation can decrease potassium in the body. View abstract. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. O'Connell K, Kinsella J, McMahon C, Holian J, O'Riordan S. Posterior reversible encephalopathy syndrome (PRES) associated with liquorice consumption. BMJ Case Rep. 2012 Oct 19;2012. (check all that apply), What factors are most important to you? Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Am J Clin Nutr 1987;46:61-5. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. Yu IC, Tsai YF, Fang JT, Yeh MM, Fang JY, Liu CY. Available at: Large amounts of licorice can decrease potassium levels in the body. Licorice may only be helpful for the infection in people with peptic ulcer disease. Armanini, D., Mattarello, M. J., Fiore, C., Bonanni, G., Scaroni, C., Sartorato, P., and Palermo, M. Licorice reduces serum testosterone in healthy women. The dried licorice root is used for many medicinal purposes. Kraus SD, Kaminskis A. View abstract. Heidemann HT, Kreuzfelder E. Hypokalemic rhabdomyolysis with myoglobinuria due to licorice ingestion and diuretic treatment. Effects of the Japanese herbal medicine "Sho-saiko-to" (TJ-9) on in vitro interleukin-10 production by peripheral blood mononuclear cells of patients with chronic hepatitis C. Hepatology 1997;25(6):1390-1397. Licorice might change how the liver breaks down some medications. View abstract. Licorice root, or sweet root, is a common ingredient for sweetening beverages and candies. Vegetables as a source of infection with Pseudomonas aeruginosa in a University and Oncology Hospital of Rio de Janeiro. Correa CM, Tibana A, Gontijo-Filho PP. Zhongguo Zhong.Yao Za Zhi. View abstract. Licorice might change how the liver breaks down some medications. Postgrad Med J 1980;56(657):526-529. Before taking licorice, talk to your healthcare provider if you are taking any medications that are changed by the liver. Gibertoni, M., Bonito, V., Colombo, A., Falasca, A., and Nichelli, P. [Licorice-induced myopathy. Blood Press. Medications for high blood pressure (Antihypertensive drugs) interacts with LICORICE. J Am Coll.Nutr 2007;26(3):209-218. High levels of a hormone called prolactin in the blood (hyperprolactinemia).. Ai, M., Yamaguchi, T., Odaka, T., Mitsuhashi, K., Shishido, T., Yan, J., Seza, A., and Saisho, H. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. View abstract. Nephol Dial Transplant 1999;14:218-20. View abstract. Licorice, tobacco chewing, and hypertension. View abstract. Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., and Bielenberg, J. Antiviral effects of Glycyrrhiza species. There are two types of licorice supplements -- those made with the whole licorice root and those made with deglycyrrhizinated licorice, or DGL, which has had the substance glycyrrhiza removed to minimize side effects from using licorice. View abstract. Hawrelak, J. Engqvist, A., von Feilitzen, F., Pyk, E., and Reichard, H. Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. Prebiotic digestion and fermentation. Whole licorice root can reduce testosterone levels in men, increase a pregnant woman’s risk for premature delivery and even stimulate the growth of breast cancer cells, says the University of Pittsburgh Medical Center 1. Kondo K1, Shiba M, Nakamura R, Morota T, Shoyama Y. J Am Diet Assoc 2010;110(6):865-8. [Clinical observation on auxiliary treatment of hormone dependence dermatitis by shufeng liangxue decoction]. View abstract. View abstract. View abstract. View abstract. Peters, M. C., Tallman, J. 2010;16(4):216-218. Nutrition 2002;18(3):268-273. Luchon, L., Meyrier, A., and Paillard, F. [Hypokalemia without arterial hypertension by licorice poisoning]. N Engl J Med 1999;341:1158. Medicine (Baltimore) 2019;98(35):e16601. Ann Noninvasive Electrocardiol. Taking licorice along with estrogen pills might decrease the effects of estrogen pills. Licorice root contains glycyrrhizin, which is also called glycyrrhizic acid. Eisenburg, J. Eur J Drug Metab Pharmacokinet. Sontia B, Mooney J, Gaudet L, Touyz RM. Luo, Y. G., Liu, Y. Q., and Hu, J. 2000;20(3):173-175. Mouth sores (lichen planus). A digestive tract infection that can lead to ulcers (Helicobacter pylori or H. pylori) . Zhongguo Zhong.Yao Za Zhi. Gardner Z, McGuffin M. Boca Raton, FL: CRC Press, 2013. Clin Exp Obstet Gynecol 2013;40(1):141-143. Willi R, Pfab F, Huss-Marp J, et al. Lee YS, Lorenzo BJ, Koufis T, et al. I have tried other brands of liquorice tea but they seemed to have very little liquorice flavour. Tea that contains licorice root can also help soothe your throat and reduce the severity of other cold symptoms. Menati L, Khaleghinezhad K, Tadayon M, Siahpoosh A. J Clin Anesth 2019;54:25-32. Wilson, J. View abstract. Russo S, Mastropasqua M, Mosetti MA, et al. Minerva Med 2008;99(1):91-94. Licorice root can be found growing in Europe, the Mediterranean and Asia, and it’s been used for thousands of years and dozens of purposes like to soothe an upset tummy or boost your immunity! Rev Med Brux 2008;29(5):490-493. An Med Interna 1995;12(1):33-35. View abstract. Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. View abstract. Eur J Clin Pharmacol 2010;66(8):805-810. Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. Klin Wochenschr 1983;61:303-5. Preterm birth and licorice consumption during pregnancy. 2003;131(1):19-24. Br J Clin Pract 1972;26(12):563-566. Int J Food Sci Nutr 2011;62(2):164-70. Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 83rd Annual Meeting of the Endocrine Society, June 20-23 2001;abstract P1-573. Mol Cell Endocrinol. View abstract. Olsen NJ, Branch VK, Jonnala G, Seskar M, Cooper M. Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee. Chinese herbal medicine for atopic eczema. Dental plaque. Scand.J Gastroenterol. Eriksson JW, Carlberg B, Hillom V. Life-threatening ventricular tachycardia due to liquorice-induced hypokalemia. Horm.Res 1999;52(5):253-255. Pontefract cakes can be bad for you: refractory hypertension and liquorice excess. View abstract. Tu, J. H., He, Y. J., Chen, Y., Fan, L., Zhang, W., Tan, Z. R., Huang, Y. F., Guo, D., Hu, D. L., Wang, D., and Hong-Hao Zhou. Herb-Drug Interaction Potential of Licorice Extract and Paclitaxel: A Pharmacokinetic Study in Rats. J Med Liban 2012;60(2):117-119. View abstract. View abstract. View abstract. J Endocrinol Invest 1990;13(10):847-848. Am J Psychiatry 1994;151:617-8. Dehours E, Vallé B, Rougé-Bugat ME, Florent B, Bounes V, Franchitto N. Suspected hypokalaemia following liquorice ingestion on board ship. 1991;78(1-2):1-6. Cancer Res 2000;60:5704-9.. View abstract. The licorice root plant belongs to Mediterranean, Europe, and Russia that is scientifically known as Glycyrrhiza glabra. Large amounts of licorice seem to increase blood pressure. Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Nihon Jinzo Gakkai Shi 2010;52(1):80-85. Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Gut 1969;10:299-302. View abstract. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Am J Epidemiol 2001;153:1085-8. Int Endod.J 2011;44(1):51-58. Evaluation of contextual and demographic factors on licorice effects on reducing hot flashes in postmenopause women. Chatterjee, N., Domoto-Reilly, K., Fecci, P. E., Schwamm, L. H., and Singhal, A. Topical forms of this product are for use only on the skin. Amaryan G, Astvatsatryan V, Gabrielyan E, et al. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. View abstract. View abstract. The appropriate dose of chicory for use as treatment depends on several factors such as the user's age, health, and several other conditions. Warfarin (Coumadin) interacts with LICORICE. Do not take topical (for the skin) licorice by mouth. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. View abstract. Check with your health care professional before using herbs or herbal supplements. Gen Dent 2008;56(2):206-210. J Pharmacol Exp Ther 2006;316:1369-77. View abstract. Anesth Analg. Z. Am J Clin Nutr 2001;73:415S-420S. Anesth Analg 2009;109(1):77-81. de Kraker, J. W., Franssen, M. C., Joerink, M., de Groot, A., and Bouwmeester, H. J. Biosynthesis of costunolide, dihydrocostunolide, and leucodin. View abstract. Fermented milk containing Lactobacillus paracasei and Glycyrrhiza glabra has a beneficial effect in patients with Helicobacter pylori infection: a randomized, double-blind, placebo-controlled study. Journal of Clinical Therapeutics Medicine. View abstract. Das SK, Das V, Gulati AK, and et al. Chien, C. F., Wu, Y. T., and Tsai, T. H. Biological analysis of herbal medicines used for the treatment of liver diseases. Our unbeatably sweet Licorice infusion combines natural licorice root with herbs, spices and citrus peel. View abstract. Armanini, D., Castello, R., Scaroni, C., Bonanni, G., Faccini, G., Pellati, D., Bertoldo, A., Fiore, C., and Moghetti, P. Treatment of polycystic ovary syndrome with spironolactone plus licorice. Contact Dermatitis 1999;40(1):56. 2001;21(7):501-503. Am J Nephrol 2000;20:145-8. J Agric.Food Chem 8-14-2002;50(17):4743-4748. From this root, the sweet flavor can be extracted. You're also likely to have tests to check for damage to your esophagus and stomach, as well as for precancerous changes.Tests may include: 1. CJEM 2009;11(1):94-96. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Biol Pharm Bull. View abstract. J Altern Complement Med. Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. Messier, C., Epifano, F., Genovese, S., and Grenier, D. Licorice and its potential beneficial effects in common oro-dental diseases. Badr, A. E., Omar, N., and Badria, F. A. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. Davis EA, Morris DJ. View abstract. View abstract. View abstract. View abstract. A double-blind, randomized, placebo-controlled trial on the effects of an herbal preparation in patients with functional dyspepsia [Abstract]. Korri, H., Awada, A., Baajour, W., Beaini, M., and Nasreddine, W. [Rapidly progressing quadriparesis secondary to licorice (souss) intoxication]. Practitioner 1973;210:820-3. Eur J Obstet Gynecol.Reprod Biol 2007;131(1):61-67. View abstract. Phytomedicine 2003;10:271-85. View abstract. View abstract. Biofactors 2009;35(1):98-104. 2020;247:112226. Br J Dermatol 1992;126:179-84. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Sheehan MP, Atherton DJ. View abstract. Cassano, N., Mantegazza, R., Battaglini, S., Apruzzi, D., Loconsole, F., and Vena, G. A. View abstract. View abstract. "Water pills" can also decrease potassium in the body. View abstract. Armanini D, De Palo CB, Mattarello MJ, et al. 2014 Jun;20(6):516-20. 1999;15:499-523. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . View abstract. Int J Dermatol 1999;38:387-92 . Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. View abstract. Amato P, Christophe S, Mellon PL. View abstract. J Clin Hypertens (Greenwich) 2016;18(2):159-60. Ital J Neurol Sci 1983;4(4):493-497. View abstract. Asian Medical Journal 1984;26(7):423-438. J Nat Prod 1980;43(2):259-269. View abstract. View abstract. Some medications are changed and broken down by the liver. Finke, B., Stahl, B., Pritschet, M., Facius, D., Wolfgang, J., and Boehm, G. Preparative continuous annular chromatography (P-CAC) enables the large-scale fractionation of fructans. Lancet 2000;355(9198):134-138. View abstract. WebMD does not provide medical advice, diagnosis or treatment. Chen, M. F., Shimada, F., Kato, H., Yano, S., and Kanaoka, M. Effect of oral administration of glycyrrhizin on the pharmacokinetics of prednisolone. Fuhrman, B., Volkova, N., Kaplan, M., Presser, D., Attias, J., Hayek, T., and Aviram, M. Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure. van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. 2013 Sep;117(3):614-21. Ha Y, Wang T, Li J, et al. View abstract. Am J Respir.Cell Mol.Biol. Treatment of functional dyspepsia with a herbal preparation. View abstract. BMC Musculoskeletal Disord 2010;11:156. Bonito, V., Colombo, A., Falasca, A., and itching a. In men by licorice poisoning ] guinea pig kidney by furosemide, and., J. C. Mechanism of action of glycyrrhizic acid: the assessment of double-blind! Licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft of! 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